A Computational Workflow for Designing Libraries of sgRNAs for CRISPR-Mediated Base Editing, and much more
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Jul 22, 2026 - Python
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base-editing
Here are 10 public repositories matching this topic...
Protein language models-assisted optimization of a uracil-N-glycosylase variant enables programmable T-to-G and T-to-C base editing
enzyme mutation protein fitness-landscape crispr-cas9 protein-engineering base-editing llm large-language direct-evoluation direct-evolution large-langage-models
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Jun 6, 2024 - Jupyter Notebook
Base Editing screens' Activity-Normalized variant effect size estimation
screen bayesian-network crispr probabilistic-programming-language base-editing count-data-modeling ngs-sequencing-data
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Aug 13, 2025 - Python
A variant-first, multi-modality CRISPR design framework that unifies SpCas9 nuclease, base-editor, and prime-editor chemistries under a single typed interface to deliver ranked candidate edits complete with calibrated uncertainty intervals, predicted outcome distributions, and ancestry-stratified, population-aware off-target safety reporting.
python rust machine-learning bioinformatics deep-learning genomics computational-biology crispr variant-calling clinvar uncertainty-estimation genome-editing benchmark-datasets pyo3 base-editing populationgenetics prime-editing haplotype-mapping off-target-analysis guide-rna-design
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Aug 12, 2026 - Python
A declarative DSL and compiler for reproducible gene-editing design — with LLM agents and an MCP server so any AI agent can drive it safely.
python bioinformatics compiler dsl mcp computational-biology crispr genome-editing base-editing gene-editing guide-rna prime-editing llm-agents mcp-server
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Jul 17, 2026 - Python
Computational pipeline for designing celiac-safe wheat by editing gluten genes to remove TG2 deamidation sites
python bioinformatics pipeline genomics agriculture biology computational-biology open-science crispr genetic genome-editing wheat food-science celiac-disease base-editing prime-editing gmos
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Aug 23, 2026 - Python
Research safety-triage workflow for CRISPR base editing in sickle cell disease and beta-thalassemia; covers bystanders, off-targets, HBG1/HBG2 risks, and evidence.
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Aug 25, 2026 - Python
AI-assisted platform for designing CRISPR experiments — from target selection to bench-ready protocols
python bioinformatics crispr gradio base-editing gene-editing guide-rna research-tools crispri prime-editing crispor crispra
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Apr 13, 2026 - Python
Universal base editing and CRISPR screen analysis tool.
data-visualization editing crispr-analysis crispr base base-editing crispr-screen-analysis crispr-screen
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Jun 8, 2026 - HTML
Beam Therapeutics * — independent third-party profile of a public API surface, by API Evangelist. Beam Therapeutics is a biotechnology company pioneering precision genetic medicines through base editing, a technology that makes precise, predictable, and efficient single-base changes to the genome without cutting the DNA double helix.
company life-sciences biotechnology precision-medicine base-editing gene-editing apis-json therapeutics genetic-medicine
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Sep 1, 2026
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