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Contributor submission gsfI #880

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8ffe150
Add submission UUID file
mite-bot Aug 14, 2026
60694f7
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mite-bot Aug 14, 2026
9b36114
Delete mite_data/data/252df45a-97bf-11f1-a881-7d5f8d37e7b5.json
mite-bot Aug 27, 2026
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mite-bot Aug 27, 2026
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97 changes: 97 additions & 0 deletions mite_data/data/MITE9999999.json
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{
"accession": "MITE9999999",
"status": "active",
"comment": "Single chlorination of griseophenone C in the griseofulvin pathway yielding griseophenone B.",
"changelog": [
{
"version": "1",
"date": "2026-08-14",
"contributors": [
"0009-0000-8651-1669"
],
"reviewers": [
"0000-0002-4540-6501"
],
"comment": "Edited text"
}
],
"enzyme": {
"name": "gsfI",
"description": "Flavin-dependent halogenase",
"references": [
"doi:10.1021/cb400541z",
"doi:10.1016/j.chembiol.2010.03.015"
],
"databaseIds": {
"uniprot": "D7PI14",
"genpept": "ADI24948.1",
"mibig": "BGC0000070"
},
"cofactors": {
"organic": [
"FAD",
"NADP"
]
}
},
"reactions": [
{
"tailoring": [
"Halogenation"
],
"description": "Single chlorination of griseophenone C yielding griseophenone B.",
"reactionSMARTS": "[#6:1]-[#6:2]1:[#6:7](-[#6:8](-[#6:10]2:[#6:15](-[#8:16]):[#6:14]:[#6:13](-[#8:17]-[#6:18]):[#6:12]:[#6:11]:2-[#8:19])=[#8:9]):[#6:6](-[#8:20]-[#6:21]):[#6:5]:[#6:4](-[#8:22]):[#6:3]:1>>[#6:1]-[#6:2]1:[#6:7](-[#6:8](-[#6:10]2:[#6:11](-[#8:19]):[#6:12](-[Cl]):[#6:13](-[#8:17]-[#6:18]):[#6:14]:[#6:15]:2-[#8:16])=[#8:9]):[#6:6](-[#8:20]-[#6:21]):[#6:5]:[#6:4](-[#8:22]):[#6:3]:1",
"reactions": [
{
"substrate": "COc1cc(O)c(C(=O)c2c(C)cc(O)cc2OC)c(O)c1",
"products": [
"COc1cc(O)c(C(=O)c2c(C)cc(O)cc2OC)c(O)c1Cl"
],
"isIntermediate": true,
"description": "Single chlorination of C2 in griseophenone C to yield griseophenone B"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay",
"Knock-out studies"
],
"references": [
"doi:10.1021/cb400541z",
"doi:10.1016/j.chembiol.2010.03.015"
]
},
"databaseIds": {
"rhea": "73931"
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Dichlorination of griseophenone C yielding griseophenone G. Only occurs in small amounts and only if GsfF was knocked out. Cytochrome P450 GsfF catalyzes the intramolecular coupling reaction of griseophenone B.",
"reactionSMARTS": "[#6:1]-[#6:2]1:[#6:7](-[#6:8](-[#6:10]2:[#6:15](-[#8:16]):[#6:14]:[#6:13](-[#8:17]-[#6:18]):[#6:12]:[#6:11]:2-[#8:19])=[#8:9]):[#6:6](-[#8:20]-[#6:21]):[#6:5]:[#6:4](-[#8:22]):[#6:3]:1>>[#6:1]-[#6:2]1:[#6:7](-[#6:8](-[#6:10]2:[#6:11](-[#8:19]):[#6:12](-[Cl]):[#6:13](-[#8:17]-[#6:18]):[#6:14](-[Cl]):[#6:15]:2-[#8:16])=[#8:9]):[#6:6](-[#8:20]-[#6:21]):[#6:5]:[#6:4](-[#8:22]):[#6:3]:1",
"reactions": [
{
"substrate": "COc1cc(O)c(C(=O)c2c(C)cc(O)cc2OC)c(O)c1",
"products": [
"COc1cc(O)cc(C)c1C(=O)c1c(O)c(Cl)c(OC)c(Cl)c1O"
],
"isIntermediate": false,
"description": "Dichlorination of C2, C4 in griseophenone C to yield griseophenone G"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay",
"Knock-out studies"
],
"references": [
"doi:10.1021/cb400541z"
]
}
}
]
}
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