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Contributor submission AutF #877

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Contributor submission AutF #877

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c0bc451
Add submission UUID file
mite-bot Aug 4, 2026
0e1d433
Update submission
mite-bot Aug 4, 2026
af805f3
Delete mite_data/data/e01d3d7c-8ff7-11f1-b09d-2de8187fb1ba.json
mite-bot Aug 5, 2026
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mite-bot Aug 5, 2026
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57 changes: 57 additions & 0 deletions mite_data/data/MITE9999999.json
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Original file line number Diff line number Diff line change
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{
"accession": "MITE9999999",
"status": "active",
"comment": "AutF is a prenyltransferase from the autumnalamide biosynthetic pathway",
"changelog": [
{
"version": "1",
"date": "2026-08-04",
"contributors": [
"0009-0008-8086-5325"
],
"reviewers": [
"0000-0002-5203-4662"
],
"comment": "New entry."
}
],
"enzyme": {
"name": "AutF",
"description": "Prenyltransferase",
"references": [
"doi:10.1039/d2cc01799g"
],
"databaseIds": {
"uniprot": "UPI0022389DA3",
"genpept": "MCW6049891.1"
}
},
"reactions": [
{
"tailoring": [
"Prenylation"
],
"description": "AutF catalyses prenylation to nitrogen of the guanidinium moiety in arginine to yield autumnalamide A",
"reactionSMARTS": "[#7:1]-[#6:2](=[#7:60])-[#7:3]-[#6:4]-[#6:5]-[#6:6]/[#6@@:7]1-[#6:11](=[#8:59])-[#7:12]-[#6@:13](-[#6:21](=[#8:58])-[#7:22]2-[#6@@:26](-[#6:27](=[#8:57])-[#7:28]-[#6:29]-[#6:30](=[#8:56])-[#7:31]-[#6@@:32](\\[#6:52]-[#6:53](-[#6:55])-[#6:54])-[#6:33](=[#8:51])-[#7:34]-[#6@:35](-[#6:40](=[#8:50])-[#7:41]-[#6@@:42](\\[#6:43]-[#6:44]3:[#6:49]:[#6:48]:[#6:47]:[#6:46]:[#6:45]:3)-[#6:9](=[#8:10])-[#7:8]-1)\\[#6:36]-[#6:37](=[#8:39])-[#8:38])/[#6:25]-[#6:24]-[#6:23]-2)\\[#6:14]-[#6:15]1:[#6:20]:[#6:19]:[#6:18]:[#6:17]:[#6:16]:1>>[#6:14]-[#6:15](=[#6:16]-[#6:17]-[#7:1]-[#6:2](=[#7:60])-[#7:3]-[#6:4]-[#6:5]-[#6:6]/[#6@@:7]1-[#6:11](=[#8:59])-[#7:12]-[#6@:13](-[#6:21](=[#8:58])-[#7:22]2-[#6@@:26](-[#6:27](=[#8:57])-[#7:28]-[#6:29]-[#6:30](=[#8:56])-[#7:31]-[#6@@:32](\\[#6:52]-[#6:53](-[#6:55])-[#6:54])-[#6:33](=[#8:51])-[#7:34]-[#6@:35](-[#6:40](=[#8:50])-[#7:41]-[#6@@:42](\\[#6:43]-[#6:44]3:[#6:45]:[#6:46]:[#6:47]:[#6:48]:[#6:49]:3)-[#6:9](=[#8:10])-[#7:8]-1)\\[#6:36]-[#6:37](=[#8:39])-[#8:38])/[#6:25]-[#6:24]-[#6:23]-2)\\[#6:14]-[#6:15]1:[#6:16]:[#6:17]:[#6:18]:[#6:19]:[#6:20]:1)-[#6:20]",
"reactions": [
{
"substrate": "CC(C)C[C@@H]1NC(=O)CNC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC1=O",
"products": [
"CC(C)=CCNC(=N)NCCC[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O"
],
"isIntermediate": false,
"description": "AutF prenylates the guanidine moiety in arginine and homoarginine. The enzyme also demonstrates a preference for linear l-Arg containing precursors over cyclic variants of autumnalamide A"
}
],
"evidence": {
"evidenceCode": [
"Inference from genomic data and chemical structure",
"In vitro assay"
],
"references": [
"doi:10.1039/d2cc01799g"
]
}
}
]
}
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