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Contributor submission PltM #876

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c2f7994
Add submission UUID file
mite-bot Aug 4, 2026
7170aaa
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mite-bot Aug 4, 2026
08552c6
Delete mite_data/data/506e3e3a-8fd2-11f1-b09d-2de8187fb1ba.json
mite-bot Aug 5, 2026
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Update MITE9999999.json
mmzdouc Aug 6, 2026
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377 changes: 377 additions & 0 deletions mite_data/data/MITE9999999.json
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{
"accession": "MITE9999999",
"status": "active",
"comment": "PltM is involved pyoluteorin biosynthesis pathway. It is a bona fide phenol-halogenase with an extraordinary substrate and halide scope, which does not accept tryptophan. Dihalogenation of substrates is much more likely. Nonproduct: Fluorinated product. Auxiliary enzyme flavin reductase not in genecluster.",
"changelog": [
{
"version": "1",
"date": "2026-08-04",
"contributors": [
"0009-0000-8651-1669"
],
"reviewers": [
"0009-0008-6482-7206",
"0000-0001-6534-6609"
],
"comment": "New entry. Reviewer 1 corrected spelling in description. Reviewer 2 fixed generalized reaction."
}
],
"enzyme": {
"name": "PltM",
"description": "Flavin-dependent halogenase",
"references": [
"doi:10.1038/s41467-019-09215-9"
],
"databaseIds": {
"uniprot": "Q9X3Q8",
"genpept": "AAD24882.1",
"mibig": "BGC0000127"
},
"cofactors": {
"organic": [
"FAD",
"NAD",
"NADP"
]
}
},
"reactions": [
{
"tailoring": [
"Halogenation"
],
"description": "Iodination of various 1,3-diphenols. Non-substrates: carboxylic acid derivatives",
"reactionSMARTS": "[#6:1]1:[#6:7](-[#8:8]):[#6:6]:[#6:4](-[#8:5]):[#6:3]:[#6:2]:1>>[#6:1]1:[#6:7](-[#8:8]):[#6:6](-I):[#6:4](-[#8:5]):[#6:3]:[#6:2]:1",
"reactions": [
{
"substrate": "c1c(/C=C/c2cc(O)cc(O)c2)ccc(O)c1",
"products": [
"c1c(/C=C/c2cc(O)c(I)c(O)c2)ccc(O)c1"
],
"isIntermediate": true,
"description": "Iodinates reservatrol."
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Single chlorination of phloroglucinol",
"reactionSMARTS": "[#6:1]1:[#6:6](-[#8:7]):[#6:5]:[#6:4](-[#8:8]):[#6:3]:[#6:2]:1-[#8:9]>>[#6:5]1(-[Cl]):[#6:6](-[#8:7]):[#6:1]:[#6:2](-[#8:9]):[#6:3]:[#6:4]:1-[#8:8]",
"reactions": [
{
"substrate": "Oc1cc(O)cc(O)c1",
"products": [
"Oc1cc(O)c(Cl)c(O)c1"
],
"isIntermediate": true,
"description": "Chlorinates phloroglucinol to 2-chlorophloroglucinol"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Dichlorination of phloroglucinol",
"reactionSMARTS": "[#6:1]1:[#6:6](-[#8:7]):[#6:5]:[#6:4](-[#8:8]):[#6:3]:[#6:2]:1-[#8:9]>>[#6:5]1(-[Cl]):[#6:6](-[#8:7]):[#6:1]:[#6:2](-[#8:9]):[#6:3](-[Cl]):[#6:4]:1-[#8:8]",
"reactions": [
{
"substrate": "Oc1cc(O)cc(O)c1",
"products": [
"Oc1cc(O)c(Cl)c(O)c1Cl"
],
"isIntermediate": true,
"description": "Chlorinates phloroglucinol to 2,4-dichlorophloroglucinol"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Single bromination of phloroglucinol",
"reactionSMARTS": "[#6:1]1:[#6:6](-[#8:7]):[#6:5]:[#6:4](-[#8:8]):[#6:3]:[#6:2]:1-[#8:9]>>[#6:5]1(-Br):[#6:6](-[#8:7]):[#6:1]:[#6:2](-[#8:9]):[#6:3]:[#6:4]:1-[#8:8]",
"reactions": [
{
"substrate": "Oc1cc(O)cc(O)c1",
"products": [
"Oc1cc(O)c(Br)c(O)c1"
],
"isIntermediate": true,
"description": "Brominates phloroglucinol to 2-bromophloroglucinol"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Single iodination of phloroglucinol",
"reactionSMARTS": "[#6:1]1:[#6:6](-[#8:7]):[#6:5]:[#6:4](-[#8:8]):[#6:3]:[#6:2]:1-[#8:9]>>[#6:5]1(-I):[#6:6](-[#8:7]):[#6:1]:[#6:2](-[#8:9]):[#6:3]:[#6:4]:1-[#8:8]",
"reactions": [
{
"substrate": "Oc1cc(O)cc(O)c1",
"products": [
"Oc1cc(O)c(I)c(O)c1"
],
"isIntermediate": true,
"description": "Iodinates phloroglucinol to 2-iodophloroglucinol"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Diiodination of phloroglucinol",
"reactionSMARTS": "[#6:1]1:[#6:6](-[#8:7]):[#6:5]:[#6:4](-[#8:8]):[#6:3]:[#6:2]:1-[#8:9]>>[#6:5]1(-I):[#6:6](-[#8:7]):[#6:1]:[#6:2](-[#8:9]):[#6:3](-I):[#6:4]:1-[#8:8]",
"reactions": [
{
"substrate": "Oc1cc(O)cc(O)c1",
"products": [
"Oc1cc(O)c(I)c(O)c1I"
],
"isIntermediate": true,
"description": "Iodinates phloroglucinol to 2,4-iodophloroglucinol"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Single Chlorination of resveratrol",
"reactionSMARTS": "[#6:1]1:[#6:6](-[#6:7]=[#6:8]-[#6:9]2:[#6:14]:[#6:13](-[#8:15]):[#6:12]:[#6:11](-[#8:16]):[#6:10]:2):[#6:5]:[#6:4]:[#6:3](-[#8:17]):[#6:2]:1>>[#6:1]1:[#6:6](-[#6:7]=[#6:8]-[#6:9]2:[#6:14]:[#6:13](-[#8:15]):[#6:12](-[Cl]):[#6:11](-[#8:16]):[#6:10]:2):[#6:5]:[#6:4]:[#6:3](-[#8:17]):[#6:2]:1",
"reactions": [
{
"substrate": "Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1",
"products": [
"Oc1ccc(/C=C/c2cc(O)c(Cl)c(O)c2)cc1"
],
"isIntermediate": true,
"description": "Chlorinates resveratrol"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Dichlorination of resorcinol",
"reactionSMARTS": "[#6:1]1:[#6:5]:[#6:6]:[#6:4](-[#8:8]):[#6:2]:[#6:3]:1-[#8:7]>>[#6:6]1(-[Cl]):[#6:5]:[#6:1](-[Cl]):[#6:3](-[#8:7]):[#6:2]:[#6:4]:1-[#8:8]",
"reactions": [
{
"substrate": "Oc1cccc(O)c1",
"products": [
"Oc1cc(O)c(Cl)cc1Cl"
],
"isIntermediate": true,
"description": "Chlorinates resorcinol to 4,6-dichlororesorcinol"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Dibromination of resorcinol",
"reactionSMARTS": "[#6:1]1:[#6:5]:[#6:6]:[#6:4](-[#8:8]):[#6:2]:[#6:3]:1-[#8:7]>>[#6:6]1(-Br):[#6:5]:[#6:1](-Br):[#6:3](-[#8:7]):[#6:2]:[#6:4]:1-[#8:8]",
"reactions": [
{
"substrate": "Oc1cccc(O)c1",
"products": [
"Oc1cc(O)c(Br)cc1Br"
],
"isIntermediate": true,
"description": "Brominates resorcinol to 4,6-bromoresorcinol"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Dichlorination of 2-chlororesorcinol",
"reactionSMARTS": "[#6:1]1:[#6:5]:[#6:6]:[#6:4](-[#8:8]):[#6:2](-[Cl]):[#6:3]:1-[#8:7]>>[#6:6]1(-[Cl]):[#6:5]:[#6:1](-[Cl]):[#6:3](-[#8:7]):[#6:2](-[Cl]):[#6:4]:1-[#8:8]",
"reactions": [
{
"substrate": "Oc1cccc(O)c1Cl",
"products": [
"Oc1c(Cl)cc(Cl)c(O)c1Cl"
],
"isIntermediate": true,
"description": "Chlorinates 2-chlororesorcinol to 2,4,6-dichlororesorcinol"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Dichlorination of 3,5-dihydroxybenzyl alcohol",
"reactionSMARTS": "[#6:1]1:[#6:5](-[#6]-[#8]):[#6:6]:[#6:4](-[#8:8]):[#6:2]:[#6:3]:1-[#8:7]>>[#6:1]1(-[Cl]):[#6:5](-[#6]-[#8]):[#6:6](-[Cl]):[#6:4](-[#8:8]):[#6:2]:[#6:3]:1-[#8:7]",
"reactions": [
{
"substrate": "OCc1cc(O)cc(O)c1",
"products": [
"OCc1c(Cl)c(O)cc(O)c1Cl"
],
"isIntermediate": true,
"description": "Chlorinates 3,5-Dihydroxybenzyl alcohol to 2,6-dichloro-3,5-dihydroxybenzyl alcohol"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Dichlorination of phloroacetophenone",
"reactionSMARTS": "[#6:1]1:[#6:5](-[#8:9]):[#6:6]:[#6:4](-[#8:8]):[#6:2](-[#6:10](=[#8:12])-[#6:11]):[#6:3]:1-[#8:7]>>[#6:6]1(-[Cl]):[#6:5](-[#8:9]):[#6:1](-[Cl]):[#6:3](-[#8:7]):[#6:2](-[#6:10](=[#8:12])-[#6:11]):[#6:4]:1-[#8:8]",
"reactions": [
{
"substrate": "CC(=O)c1c(O)cc(O)cc1O",
"products": [
"CC(=O)c1c(O)c(Cl)c(O)c(Cl)c1O"
],
"isIntermediate": true,
"description": "Dichlorination of phloroacetophenone to 3,5-chloro-phloroacetophenon"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
},
{
"tailoring": [
"Halogenation"
],
"description": "Dichlorination of 3-aminophenol",
"reactionSMARTS": "[#6:1]1:[#6:5]:[#6:6]:[#6:4](-[#7:8]):[#6:2]:[#6:3]:1-[#8:7]>>[#6:1]1(-[Cl]):[#6:5]:[#6:6](-[Cl]):[#6:4](-[#7:8]):[#6:2]:[#6:3]:1-[#8:7]",
"reactions": [
{
"substrate": "Nc1cccc(O)c1",
"products": [
"Nc1cc(O)c(Cl)cc1Cl"
],
"isIntermediate": true,
"description": "Chlorinates 3-aminophenol to 4,6-chloro-3-aminophenol"
}
],
"evidence": {
"evidenceCode": [
"Heterologous expression",
"In vitro assay"
],
"references": [
"doi:10.1038/s41467-019-09215-9"
]
}
}
]
}
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