From 9dde6db83560f7c54d076b3600ef2b16d1f53059 Mon Sep 17 00:00:00 2001
From: mite-bot <zdoucmm@gmail.com>
Date: Sat, 29 Aug 2026 12:01:52 +0200
Subject: [PATCH 1/2] Add submission UUID file

---
 .../18e08012-a38d-11f1-a881-7d5f8d37e7b5.json | 44 +++++++++++++++++++
 1 file changed, 44 insertions(+)
 create mode 100644 mite_data/data/18e08012-a38d-11f1-a881-7d5f8d37e7b5.json

diff --git a/mite_data/data/18e08012-a38d-11f1-a881-7d5f8d37e7b5.json b/mite_data/data/18e08012-a38d-11f1-a881-7d5f8d37e7b5.json
new file mode 100644
index 00000000..43ba7c93
--- /dev/null
+++ b/mite_data/data/18e08012-a38d-11f1-a881-7d5f8d37e7b5.json
@@ -0,0 +1,44 @@
+{
+    "accession": "MITE9999999",
+    "status": "pending",
+    "changelog": [
+        {
+            "version": "1",
+            "date": "2026-08-29",
+            "contributors": [
+                "0009-0008-8086-5325"
+            ],
+            "reviewers": [
+                "BBBBBBBBBBBBBBBBBBBBBBBB"
+            ],
+            "comment": "New entry."
+        }
+    ],
+    "enzyme": {
+        "name": "AbeH",
+        "databaseIds": {
+            "uniprot": "UPI00020D9059",
+            "genpept": ""
+        },
+        "references": [
+            "doi:"
+        ]
+    },
+    "reactions": [
+        {
+            "evidence": {
+                "evidenceCode": [],
+                "references": [
+                    "doi:"
+                ]
+            },
+            "reactions": [
+                {
+                    "products": [
+                        ""
+                    ]
+                }
+            ]
+        }
+    ]
+}
\ No newline at end of file

From 2bc51381d4f465a3b0958a5c9e923bcdee597d0f Mon Sep 17 00:00:00 2001
From: mite-bot <zdoucmm@gmail.com>
Date: Sat, 29 Aug 2026 13:01:56 +0200
Subject: [PATCH 2/2] Update submission

---
 .../18e08012-a38d-11f1-a881-7d5f8d37e7b5.json | 66 ++++++++++++++++---
 1 file changed, 56 insertions(+), 10 deletions(-)

diff --git a/mite_data/data/18e08012-a38d-11f1-a881-7d5f8d37e7b5.json b/mite_data/data/18e08012-a38d-11f1-a881-7d5f8d37e7b5.json
index 43ba7c93..e2a7ef32 100644
--- a/mite_data/data/18e08012-a38d-11f1-a881-7d5f8d37e7b5.json
+++ b/mite_data/data/18e08012-a38d-11f1-a881-7d5f8d37e7b5.json
@@ -1,6 +1,7 @@
 {
     "accession": "MITE9999999",
     "status": "pending",
+    "comment": "Tryptophan 5-halogenase",
     "changelog": [
         {
             "version": "1",
@@ -16,29 +17,74 @@
     ],
     "enzyme": {
         "name": "AbeH",
+        "description": "Flavin-dependent halogenase",
+        "references": [
+            "doi:10.1021/ja2022653",
+            "doi:10.1021/acsomega.4c09590"
+        ],
         "databaseIds": {
             "uniprot": "UPI00020D9059",
-            "genpept": ""
+            "genpept": "AEF32095.1",
+            "mibig": "BGC0001333"
         },
-        "references": [
-            "doi:"
-        ]
+        "cofactors": {
+            "organic": [
+                "FAD"
+            ]
+        }
     },
     "reactions": [
         {
+            "tailoring": [
+                "Halogenation"
+            ],
+            "description": "AbeH chlorinates tryptophan in the biosynthesis of BE-54017.",
+            "reactionSMARTS": "[#7:1]-[#6:2](-[#6:6]-[#6:7]1:[#6:15]:[#7:14]:[#6:9]2:[#6:10]:[#6:11]:[#6:12]:[#6:13]:[#6:8]:1:2)-[#6:3](=[#8:5])-[#8:4]>>[#7:1]-[#6:2](-[#6:6]-[#6:7]1:[#6:15]:[#7:14]:[#6:9]2:[#6:10]:[#6:11]:[#6:12](:[#6:13]:[#6:8]:1:2)-[Cl])-[#6:3](=[#8:5])-[#8:4]",
+            "reactions": [
+                {
+                    "substrate": "NC(Cc1c[nH]c2ccccc12)C(=O)O",
+                    "products": [
+                        "NC(Cc1c[nH]c2ccc(Cl)cc12)C(=O)O"
+                    ],
+                    "isIntermediate": true,
+                    "description": "AbeH chlorinates and brominates Trp at C5 and can halogenate other substrates with phenyl, quinoline, or indole groups."
+                }
+            ],
             "evidence": {
-                "evidenceCode": [],
+                "evidenceCode": [
+                    "Heterologous expression",
+                    "In vitro assay",
+                    "Knock-out studies"
+                ],
                 "references": [
-                    "doi:"
+                    "doi:10.1021/acsomega.4c09590",
+                    "doi:10.1021/ja2022653"
                 ]
-            },
+            }
+        },
+        {
+            "tailoring": [
+                "Halogenation"
+            ],
+            "description": "AbeH brominates Trp at C5",
+            "reactionSMARTS": "[#7:1]-[#6:2](-[#6:6]-[#6:7]1:[#6:15]:[#7:14]:[#6:9]2:[#6:10]:[#6:11]:[#6:12]:[#6:13]:[#6:8]:1:2)-[#6:3](=[#8:5])-[#8:4]>>[#7:1]-[#6:2](-[#6:6]-[#6:7]1:[#6:15]:[#7:14]:[#6:9]2:[#6:10]:[#6:11]:[#6:12](:[#6:13]:[#6:8]:1:2)-Br)-[#6:3](=[#8:5])-[#8:4]",
             "reactions": [
                 {
+                    "substrate": "NC(Cc1c[nH]c2ccccc12)C(=O)O",
                     "products": [
-                        ""
-                    ]
+                        "NC(Cc1c[nH]c2ccc(Br)cc12)C(=O)O"
+                    ],
+                    "isIntermediate": false
                 }
-            ]
+            ],
+            "evidence": {
+                "evidenceCode": [
+                    "In vitro assay"
+                ],
+                "references": [
+                    "doi:10.1021/acsomega.4c09590"
+                ]
+            }
         }
     ]
 }
\ No newline at end of file