From 9f47af1da4954ffc4edc48011dd5790929826c93 Mon Sep 17 00:00:00 2001 From: mite-bot Date: Sun, 9 Aug 2026 17:30:19 +0200 Subject: [PATCH 1/2] Add submission UUID file --- .../e1a62786-93ed-11f1-85b4-ff7ca264f957.json | 44 +++++++++++++++++++ 1 file changed, 44 insertions(+) create mode 100644 mite_data/data/e1a62786-93ed-11f1-85b4-ff7ca264f957.json diff --git a/mite_data/data/e1a62786-93ed-11f1-85b4-ff7ca264f957.json b/mite_data/data/e1a62786-93ed-11f1-85b4-ff7ca264f957.json new file mode 100644 index 00000000..a58fe4bd --- /dev/null +++ b/mite_data/data/e1a62786-93ed-11f1-85b4-ff7ca264f957.json @@ -0,0 +1,44 @@ +{ + "accession": "MITE9999999", + "status": "pending", + "changelog": [ + { + "version": "1", + "date": "2026-08-09", + "contributors": [ + "0009-0008-8086-5325" + ], + "reviewers": [ + "BBBBBBBBBBBBBBBBBBBBBBBB" + ], + "comment": "New entry." + } + ], + "enzyme": { + "name": "PasB", + "databaseIds": { + "uniprot": "UPI00018343E4", + "genpept": "" + }, + "references": [ + "doi:" + ] + }, + "reactions": [ + { + "evidence": { + "evidenceCode": [], + "references": [ + "doi:" + ] + }, + "reactions": [ + { + "products": [ + "" + ] + } + ] + } + ] +} \ No newline at end of file From 155254740353ed936c2650239617b436f43f39b1 Mon Sep 17 00:00:00 2001 From: mite-bot Date: Sun, 9 Aug 2026 18:45:32 +0200 Subject: [PATCH 2/2] Update submission --- .../e1a62786-93ed-11f1-85b4-ff7ca264f957.json | 68 ++++++++++++++++--- 1 file changed, 58 insertions(+), 10 deletions(-) diff --git a/mite_data/data/e1a62786-93ed-11f1-85b4-ff7ca264f957.json b/mite_data/data/e1a62786-93ed-11f1-85b4-ff7ca264f957.json index a58fe4bd..4ab0b715 100644 --- a/mite_data/data/e1a62786-93ed-11f1-85b4-ff7ca264f957.json +++ b/mite_data/data/e1a62786-93ed-11f1-85b4-ff7ca264f957.json @@ -1,6 +1,7 @@ { "accession": "MITE9999999", "status": "pending", + "comment": "PasB is a daropeptide maturases possess intrinsic multifunctionality, catalyzing the formation of ether cross-link on \u03a91\u2013X2\u2013\u03a93 motif (WTFRF), C\u2013C cross-linking on \u03a91\u2013X2\u2013X3 motif (WTKRF) and Ser oxidation on \u03a91\u2013X2\u2013S3 motif (WTSRF).", "changelog": [ { "version": "1", @@ -16,29 +17,76 @@ ], "enzyme": { "name": "PasB", + "description": "Radical SAM enzyme", + "references": [ + "doi:10.1021/jacs.3c04355", + "doi:10.1073/pnas.2617449123" + ], "databaseIds": { "uniprot": "UPI00018343E4", - "genpept": "" + "genpept": "CAQ83239.1" }, - "references": [ - "doi:" - ] + "cofactors": { + "organic": [ + "SAM" + ], + "inorganic": [ + "FeS" + ] + } }, "reactions": [ { + "tailoring": [ + "Cyclization" + ], + "description": "PasB catalyzes the formation of ether cross-link between Trp1-Phe3 on the core motif WTFRF", + "reactionSMARTS": 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+ "reactions": [ + { + "substrate": "CSCCC(N)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CO)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)O)C(C)O)C(C)O)C(C)O)C(C)C", + "products": [ + "CSCCC(N)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CO)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC1Cc2c[nH]c3c(cccc23)OC(c2ccccc2)C(C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc2ccccc2)C(=O)O)NC(=O)C(C(C)O)NC1=O)C(C)O)C(C)O)C(C)C" + ], + "isIntermediate": true, + "description": "PasB catalyzes ether cross-linking on core motif of precursor peptide PasA followed by proteolysis by unknown E. coli protease to release the ether cross-linked pentapeptide (WTFRF) named photorhaptin A. PasA precursor peptide: MNVSTKNHDAKLFPQGDNSKNRDNRETNNNRDKSEYENYPELSQWTFRF" + } + ], "evidence": { - "evidenceCode": [], + "evidenceCode": [ + "Heterologous expression", + "In vitro assay", + "Site-directed mutagenesis" + ], "references": [ - "doi:" + "doi:10.1021/jacs.3c04355" ] - }, + } + }, + { + "tailoring": [ + "Cyclization" + ], + "description": "PasB catalyzes the formation of C\u2013C cross-link between Trp1-Lys3 on the non-native core motif WTKRF", + "reactionSMARTS": 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"reactions": [ { + "substrate": "CSCCC(N)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CO)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc1ccccc1)C(=O)O)C(C)O)C(C)O)C(C)O)C(C)C", "products": [ - "" - ] + "CSCCC(N)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CO)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(Cc1c[nH]cn1)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CO)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCC(=O)O)C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC1Cc2c[nH]c3cc(ccc23)C(CCCN)C(C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc2ccccc2)C(=O)O)NC(=O)C(C(C)O)NC1=O)C(C)O)C(C)O)C(C)C" + ], + "isIntermediate": true } - ] + ], + "evidence": { + "evidenceCode": [ + "Heterologous expression", + "Site-directed mutagenesis" + ], + "references": [ + "doi:10.1021/jacs.3c04355" + ] + } } ] } \ No newline at end of file