diff --git a/src/sentry/api/base.py b/src/sentry/api/base.py
index e7e66d1d602ed8..cb735c79ea7f4a 100644
--- a/src/sentry/api/base.py
+++ b/src/sentry/api/base.py
@@ -227,6 +227,7 @@ class Endpoint(APIView):
     publish_status: dict[HTTP_METHOD_NAME, ApiPublishStatus] = {}
     rate_limits: RateLimitConfig = DEFAULT_RATE_LIMIT_CONFIG
     enforce_rate_limit: bool = settings.SENTRY_RATELIMITER_ENABLED
+    servers: list[dict[str, Any]] | None = None
 
     def build_cursor_link(self, request: HttpRequest, name: str, cursor: Cursor) -> str:
         if request.GET.get("cursor") is None:
diff --git a/src/sentry/api/endpoints/seer_models.py b/src/sentry/api/endpoints/seer_models.py
index 06cca95dc2722b..de9cca17e784df 100644
--- a/src/sentry/api/endpoints/seer_models.py
+++ b/src/sentry/api/endpoints/seer_models.py
@@ -50,6 +50,7 @@ class SeerModelsEndpoint(Endpoint):
     }
     owner = ApiOwner.ML_AI
     permission_classes = ()
+    servers = [{"url": "https://{region}.sentry.io"}]
 
     enforce_rate_limit = True
     rate_limits = RateLimitConfig(
@@ -72,6 +73,9 @@ def get(self, request: Request) -> Response:
 
         Returns the list of AI models that are currently used in production in Seer.
         This endpoint does not require authentication and can be used to discover which models Seer uses.
+
+        Requests to this endpoint should use the region-specific domain
+        eg. `us.sentry.io` or `de.sentry.io`
         """
         cached_data = cache.get(SEER_MODELS_CACHE_KEY)
         if cached_data is not None:
diff --git a/src/sentry/apidocs/hooks.py b/src/sentry/apidocs/hooks.py
index 4acea4cb0de22c..b46f48bd61e0cc 100644
--- a/src/sentry/apidocs/hooks.py
+++ b/src/sentry/apidocs/hooks.py
@@ -103,10 +103,21 @@ class CustomGenerator(SchemaGenerator):
     endpoint_inspector_cls = CustomEndpointEnumerator
 
 
+# Collected during preprocessing, used in postprocessing
+_ENDPOINT_SERVERS: dict[str, list[dict[str, Any]]] = {}
+
+
 def custom_preprocessing_hook(endpoints: Any) -> Any:  # TODO: organize method, rename
+    _ENDPOINT_SERVERS.clear()
+
     filtered = []
     ownership_data: dict[ApiOwner, dict] = {}
     for path, path_regex, method, callback in endpoints:
+        # Collect servers from endpoint class for postprocessing
+        endpoint_servers = getattr(callback.view_class, "servers", None)
+        if endpoint_servers is not None:
+            _ENDPOINT_SERVERS[path] = endpoint_servers
+
         owner_team = callback.view_class.owner
         if owner_team not in ownership_data:
             ownership_data[owner_team] = {
@@ -222,6 +233,12 @@ def _validate_request_body(
 
 
 def custom_postprocessing_hook(result: Any, generator: Any, **kwargs: Any) -> Any:
+    # Add servers override from endpoint class definitions
+    for path, servers in _ENDPOINT_SERVERS.items():
+        if path in result["paths"]:
+            for method_info in result["paths"][path].values():
+                method_info["servers"] = servers
+
     _fix_issue_paths(result)
 
     # Fetch schema component references
diff --git a/tests/apidocs/test_hooks.py b/tests/apidocs/test_hooks.py
index 68d2193e1482b9..f6e288a3507488 100644
--- a/tests/apidocs/test_hooks.py
+++ b/tests/apidocs/test_hooks.py
@@ -1,6 +1,49 @@
 from unittest import TestCase
 
-from sentry.apidocs.hooks import custom_postprocessing_hook
+from sentry.apidocs.hooks import _ENDPOINT_SERVERS, custom_postprocessing_hook
+
+
+class EndpointServersTest(TestCase):
+    def setUp(self) -> None:
+        _ENDPOINT_SERVERS.clear()
+
+    def tearDown(self) -> None:
+        _ENDPOINT_SERVERS.clear()
+
+    def test_servers_applied_to_endpoint(self) -> None:
+        """Test that servers from _ENDPOINT_SERVERS are applied to matching paths."""
+        _ENDPOINT_SERVERS["/api/0/seer/models/"] = [{"url": "https://{region}.sentry.io"}]
+
+        result = {
+            "components": {"schemas": {}},
+            "paths": {
+                "/api/0/seer/models/": {
+                    "get": {
+                        "tags": ["Seer"],
+                        "description": "Get models",
+                        "operationId": "get models",
+                        "parameters": [],
+                    }
+                },
+                "/api/0/other/endpoint/": {
+                    "get": {
+                        "tags": ["Events"],
+                        "description": "Other endpoint",
+                        "operationId": "get other",
+                        "parameters": [],
+                    }
+                },
+            },
+        }
+
+        processed = custom_postprocessing_hook(result, None)
+
+        # Servers should be applied to the matching endpoint
+        assert processed["paths"]["/api/0/seer/models/"]["get"]["servers"] == [
+            {"url": "https://{region}.sentry.io"}
+        ]
+        # Servers should NOT be applied to non-matching endpoint
+        assert "servers" not in processed["paths"]["/api/0/other/endpoint/"]["get"]
 
 
 class FixIssueRoutesTest(TestCase):